AstraZeneca to Invest $1.5 Billion in Singapore

    CEO of AstraZeneca Pascal Soriot speaks at an announcement at AstraZeneca in Mississauga Ontario, Canada February 27, 2023. REUTERS/Carlos Osorio


    AstraZeneca is making a significant investment of $1.5 billion to build a new manufacturing site in Singapore, dedicated to producing antibody drug conjugates (ADCs). These advanced chemotherapy drugs target cancer cells more precisely, potentially replacing traditional treatments. This facility will be AstraZeneca’s first fully dedicated ADC production site and marks its first manufacturing presence in Singapore.

    Innovative Cancer Treatments

    ADCs represent a cutting-edge approach to chemotherapy. They deliver toxic drugs directly to cancer cells, sparing healthy tissue from damage. AstraZeneca’s ADC portfolio includes Enhertu, which generated over $2.5 billion in sales last year and is used to treat breast and lung cancer. Enhertu is currently produced by AstraZeneca’s Japanese partner, Daiichi Sankyo.

    Strategic Investment

    The decision to establish a dedicated ADC manufacturing site underscores the importance of these drugs to AstraZeneca’s future business strategy. Supported by Singapore’s Economic Development Board (EDB), the move is a testament to the country’s appeal as a hub for high-tech manufacturing. Although specific incentives from the Singaporean government have not been disclosed, they are believed to include tax exemptions and subsidies.

    Construction Timeline and Operational Goals

    Construction of the new site will begin this year, with operations expected to commence in 2029. Singapore, despite its limited space, has successfully attracted foreign high-tech manufacturing through generous subsidies and tax incentives. This has allowed the country to develop more advanced manufacturing capabilities compared to its Southeast Asian neighbors like Malaysia and Indonesia.

    Economic and Strategic Benefits for Singapore

    Singapore has benefited from shifts in global supply chains as companies diversify away from China. High-profile investments from companies like Siemens and Taiwan Semiconductor Manufacturing Company (TSMC) illustrate the country’s growing appeal as a manufacturing hub. For AstraZeneca, proximity to fast-growing markets in Southeast Asia is a significant advantage. Sales in these emerging markets, excluding China, increased by 24% in 2023, making it AstraZeneca’s fastest-growing region.

    AstraZeneca’s Global Expansion Plans

    AstraZeneca’s commitment to expanding its global manufacturing footprint is evident in its recent investments. In February, the company announced a $300 million investment in a new facility in Rockville, Maryland, to produce another form of advanced cancer drug. Additionally, it unveiled a $388 million investment in its Dunkirk, France, manufacturing sites to meet the growing demand for its medicines.

    CEO’s Vision and Future Prospects

    Pascal Soriot, AstraZeneca’s CEO, highlighted Singapore’s attractiveness for investment, citing its reputation for excellence in complex manufacturing. He emphasized the potential of ADCs to revolutionize cancer treatment by replacing traditional chemotherapy in various settings. This strategic investment is part of AstraZeneca’s broader plan to develop separate supply chains for the US and Europe, enhancing its global operational resilience.


    AstraZeneca’s $1.5 billion investment in a dedicated manufacturing facility in Singapore marks a pivotal step in the company’s expansion strategy. By focusing on advanced chemotherapy drugs, AstraZeneca is positioning itself at the forefront of innovative cancer treatments. The new facility not only strengthens its manufacturing capabilities but also aligns with its goal of building resilient and diversified supply chains. As AstraZeneca continues to invest in advanced drug manufacturing globally, it reinforces its commitment to improving patient outcomes through cutting-edge medical innovations.

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    CEO of AstraZeneca Pascal Soriot speaks at an announcement at AstraZeneca in Mississauga Ontario, Canada February 27, 2023. REUTERS/Carlos Osorio