Eli Lilly’s Weekly Insulin Injection As Effective As Daily Doses



    Eli Lilly, a leader in the pharmaceutical industry, recently announced groundbreaking results for its once-weekly insulin injection, efsitora. The company revealed that efsitora demonstrated blood sugar reduction comparable to traditional daily insulin injections across two significant studies involving patients with type 2 diabetes. This advancement holds the potential to significantly ease the treatment burden for diabetes patients, offering a more convenient and equally effective alternative.

    Study Highlights: Efsitora vs. Daily Insulins

    Eli Lilly’s announcement on May 16, 2024, highlighted the results of two pivotal studies comparing efsitora to commonly used daily insulins. The first study evaluated efsitora in patients both using and not using GLP-1 therapies. The findings showed that efsitora was non-inferior to insulin degludec (Tresiba), a product by Novo Nordisk, in reducing blood sugar levels. After 52 weeks, patients using efsitora saw an average reduction of 1.34% in their A1C levels—a crucial marker of blood glucose over three months—compared to a 1.26% reduction for those using insulin degludec. This study included patients who were starting insulin therapy for the first time.

    The second study, conducted over 26 weeks, demonstrated that both efsitora and insulin glargine (marketed as Basaglar by Lilly and Lantus by Sanofi) achieved a reduction of 1.07% in A1C levels. These consistent results underscore the efficacy of efsitora, positioning it as a viable alternative to daily insulin injections.

    The Significance of Once-Weekly Insulin

    The development of once-weekly insulin injections like efsitora represents a significant breakthrough in diabetes care. Traditional insulin therapy often requires daily injections, which can be burdensome and affect patient adherence. By reducing the frequency of injections to once a week, efsitora offers a more convenient solution that could improve compliance and overall quality of life for diabetes patients.

    Eli Lilly and Novo Nordisk: Leaders in Innovation

    Eli Lilly and Novo Nordisk are at the forefront of developing innovative insulin therapies. Novo Nordisk’s once-weekly insulin, icodec, has already been recommended for approval in Europe and is under regulatory review in the United States. The U.S. Food and Drug Administration (FDA) advisors are scheduled to meet next week to discuss Novo’s application for approval. This shift towards weekly insulin injections indicates a broader industry trend aimed at enhancing patient convenience and adherence.

    Market Implications and Competition

    Eli Lilly, Sanofi, and Novo Nordisk collectively control 90% of the U.S. insulin market. These companies have faced mounting political pressure to make diabetes treatments more affordable. The introduction of once-weekly insulins like efsitora and icodec could not only revolutionize patient care but also address some of the affordability and accessibility challenges associated with diabetes treatment.

    Political and Economic Considerations

    The high cost of insulin has been a contentious issue, with significant political and public pressure on pharmaceutical companies to reduce prices. Eli Lilly’s decision to cut the list prices of its most commonly prescribed insulin products, Humalog and Humulin, by 70% starting from the fourth quarter of this year is a response to such pressures. The development of more convenient treatment options like efsitora aligns with these efforts, potentially reducing the overall cost burden for patients and healthcare systems.

    Future Directions and Data Presentations

    Eli Lilly plans to present detailed data from these studies at a medical conference later this year, providing further insights into the efficacy and safety profile of efsitora. These presentations will be crucial in influencing future treatment guidelines and practices, potentially paving the way for broader adoption of weekly insulin injections.


    Eli Lilly’s introduction of efsitora, a once-weekly insulin injection, marks a significant advancement in diabetes care. The clinical studies showing its efficacy comparable to daily insulin doses highlight its potential to simplify treatment regimens and improve patient adherence. As the pharmaceutical industry continues to innovate, such developments promise to enhance the quality of life for millions of diabetes patients worldwide. With ongoing efforts to make diabetes treatments more affordable and accessible, the future of diabetes care looks promising.

    Efsitora represents a significant step forward, demonstrating that innovation in drug delivery can lead to substantial improvements in patient care. As Eli Lilly and Novo Nordisk continue to lead the charge in developing advanced insulin therapies, the landscape of diabetes treatment is poised for a transformative change. The ongoing clinical trials, regulatory reviews, and upcoming data presentations will be pivotal in shaping the future of diabetes management, offering hope for more effective and convenient treatment options for patients around the globe.

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